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Elite Edition

Can you take glutamine during chemo?

Author

Emily Dawson

Published Mar 03, 2026

Can you take glutamine during chemo?

Glutamine is a major dietary amino acid that is both a fuel and nitrogen donor for healing tissues damaged by chemotherapy and radiation. Evidence supports the benefit of oral (enteral) glutamine to reduce symptoms and improve and/or maintain quality of life of cancer patients.

Should cancer patients take glutamine?

Cancer’s need for glutamine is so great that some cancer-causing oncogenes alter how much of it the cells take up and digest. One of the best known, the gene MYC, promotes cancer in part by increasing cancer cells’ access to a steady supply of glutamine.

Does L glutamine help with chemo side effects?

Intravenous glutamine also reduced chemotherapy-induced nausea, vomiting, and diarrhea in patients with gastric or colorectal cancer (21), and enteral nutrition that includes arginine , glutamine, and omega-3 fatty acids may improve short-term survival in stage IV gastric cancer patients (22).

What supplements should not be taken during chemotherapy?

Echinacea, curcumin, St. John’s wort, valerian root, and allium (an extract of garlic) — all are examples of herbal supplements that can disrupt the toxicity-efficacy balance of chemotherapy. In addition, the doses of herbal supplements are not standardized.

What are the negative effects of glutamine?

Common side effects may include:

  • nausea, vomiting, stomach pain, gas;
  • swelling in your hands or feet;
  • muscle or joint pain, back pain;
  • headache, dizziness, tired feeling;
  • mild skin rash or itching; or.
  • dry mouth, runny nose, increased sweating.

When should I stop taking glutamine?

While L-glutamine supplementation is usually considered safe for most people, there are some who should avoid it. People with kidney disease, liver disease or Reye’s syndrome, a severe condition that can cause swelling of the liver and brain, should avoid taking L-glutamine supplements.

How does glutamine feed cancer?

The researchers explain that glutamine is carried through the body and “fed” to cancer cells via the amino acid transporter ASCT2, a type of protein. “Elevated ASCT2 levels have been linked to poor survival in many human cancers, including lung, breast, and colon,” the researchers note in their introduction.

Who should not take L-glutamine?

Does CoQ10 interfere with chemotherapy?

CoQ10 may interfere with the actions of warfarin (11) (12). Because of its antioxidant properties, it may also reduce effectiveness of chemotherapy and radiation therapy (13).

Does turmeric interfere with chemo?

Turmeric is likely safe for most people, but it should be avoided during chemotherapy, radiation or blood-thinning therapies.

Who should not take glutamine?

Does glutamine interact with any medications?

Other drugs may interact with glutamine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

What are the benefits of glutamine for cancer patients?

One study showed that glutamine given intravenously to patients receiving chemotherapy for gastric or colorectal cancer significantly reduced nausea, vomiting, and diarrhea. Preliminary studies suggest that glutamine may help treat neuropathy caused by chemotherapy. Larger confirmatory trials are needed.

Does glutamine cause peripheral neuropathy after chemotherapy?

After all 6 cycles of chemotherapy, 48% of patients in the glutamine group had no peripheral neuropathy (PN) versus only 27% in the non-glutamine group. After all 6 cycles of chemotherapy, 12% of the patients in the glutamine group had moderate-to-severe PN versus 32% in the non-glutamine group.

Does glutamine supplementation improve cold intolerance after chemotherapy?

After all 6 cycles of chemotherapy, 12% of the patients in the glutamine group had moderate-to-severe PN versus 32% in the non-glutamine group. Glutamine supplementation significantly improved cold intolerance and lessened the interference to activities of daily living.

Can I mix L-glutamine powder with other liquids?

However, I recommend using the powder form of L-glutamine, and mixing it in with cold or room temperature liquids (water or juice.) It should not be added to hot beverages because heat destroys glutamine. Glutamine therapy works best if started at the time of beginning radiation therapy or chemotherapy.